Reaction Details |
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Target | Caspase-4 |
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Ligand | BDBM223 |
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Substrate/Competitor | Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC |
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Meas. Tech. | Fluorometric Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Ki | 22000±n/a nM |
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Citation | Choong, IC; Lew, W; Lee, D; Pham, P; Burdett, MT; Lam, JW; Wiesmann, C; Luong, TN; Fahr, B; DeLano, WL; McDowell, RS; Allen, DA; Erlanson, DA; Gordon, EM; O'Brien, T Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem45:5005-22 (2002) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Caspase-4 |
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Name: | Caspase-4 |
Synonyms: | CASP-4 | CASP4 | CASP4_HUMAN | Caspase 4 | Caspase-4 subunit 1 | Caspase-4 subunit 2 | ICE(rel)-II | ICH-2 protease | ICH2 | TX protease |
Type: | Enzyme |
Mol. Mass.: | 43257.75 |
Organism: | Homo sapiens (Human) |
Description: | P49662 |
Residue: | 377 |
Sequence: | MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE
RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN
RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF
IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP
TIERLSMTRYFYLFPGN
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BDBM223 |
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Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC |
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Name: | Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC |
Synonyms: | Caspase-4 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC | Caspase-5 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC |
Type: | Peptide |
Mol. Mass.: | 584.05 |
Organism: | n/a |
Description: | Molecular Mass of WEHD |
Residue: | 4 |
Sequence: | |