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TargetCaspase-4
LigandBDBM223
Substrate/CompetitorCaspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC
Meas. Tech.Fluorometric Assay
pH7.4±n/a
Temperature298.15±n/a K
Ki 22000±n/a nM
Citation Choong, ICLew, WLee, DPham, PBurdett, MTLam, JWWiesmann, CLuong, TNFahr, BDeLano, WLMcDowell, RSAllen, DAErlanson, DAGordon, EMO'Brien, T Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem45:5005-22 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Caspase-4
Name:Caspase-4
Synonyms:CASP-4 | CASP4 | CASP4_HUMAN | Caspase 4 | Caspase-4 subunit 1 | Caspase-4 subunit 2 | ICE(rel)-II | ICH-2 protease | ICH2 | TX protease
Type:Enzyme
Mol. Mass.:43257.75
Organism:Homo sapiens (Human)
Description:P49662
Residue:377
Sequence:
MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE
RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN
RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF
IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP
TIERLSMTRYFYLFPGN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM223
Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC
Name:Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC
Synonyms:Caspase-4 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC | Caspase-5 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC
Type:Peptide
Mol. Mass.:584.05
Organism:n/a
Description:Molecular Mass of WEHD
Residue:4
Sequence:
WEHD