Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCaspase-3
LigandBDBM228
Substrate/CompetitorCaspase-3 Fluorogenic Substrate
Meas. Tech.Fluorometric Assay
pH7.4±n/a
Temperature298.15±n/a K
Ki 480±n/a nM
Citation Choong, ICLew, WLee, DPham, PBurdett, MTLam, JWWiesmann, CLuong, TNFahr, BDeLano, WLMcDowell, RSAllen, DAErlanson, DAGordon, EMO'Brien, T Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem45:5005-22 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Caspase-3
Name:Caspase-3
Synonyms:Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:31607.55
Organism:Homo sapiens (Human)
Description:n/a
Residue:277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM228
Caspase-3 Fluorogenic Substrate
Name:Caspase-3 Fluorogenic Substrate
Synonyms:Caspase-3 Fluorogenic Substrate Ac-Asp-Glu-Val-Asp-AFC | Fluorometric Tetrapeptide Ac-DEVD-AMC
Type:n/a
Mol. Mass.:1477.75
Organism:n/a
Description:AFC = 7-Amino-4-trifluoromethylcoumarin
Residue:16
Sequence:
Ac-Asp-Glu-Val-Asp-AFC