Reaction Details |
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Target | Caspase-3 |
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Ligand | BDBM252 |
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Substrate/Competitor | Caspase-3 Fluorogenic Substrate |
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Meas. Tech. | Fluorometric Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Ki | 310±n/a nM |
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Citation | Choong, IC; Lew, W; Lee, D; Pham, P; Burdett, MT; Lam, JW; Wiesmann, C; Luong, TN; Fahr, B; DeLano, WL; McDowell, RS; Allen, DA; Erlanson, DA; Gordon, EM; O'Brien, T Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem45:5005-22 (2002) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Caspase-3 |
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Name: | Caspase-3 |
Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
Type: | Hydrolase; heterotetramer of two heterodimers |
Mol. Mass.: | 31607.55 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 277 |
Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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BDBM252 |
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Caspase-3 Fluorogenic Substrate |
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Name: | Caspase-3 Fluorogenic Substrate |
Synonyms: | Caspase-3 Fluorogenic Substrate Ac-Asp-Glu-Val-Asp-AFC | Fluorometric Tetrapeptide Ac-DEVD-AMC |
Type: | n/a |
Mol. Mass.: | 1477.75 |
Organism: | n/a |
Description: | AFC = 7-Amino-4-trifluoromethylcoumarin |
Residue: | 16 |
Sequence: | |