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TargetCaspase-5
LigandBDBM223
Substrate/CompetitorCaspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC
Meas. Tech.Fluorometric Assay
pH7.4±n/a
Temperature298.15±n/a K
Ki 32000±n/a nM
Citation Choong, IC; Lew, W; Lee, D; Pham, P; Burdett, MT; Lam, JW; Wiesmann, C; Luong, TN; Fahr, B; DeLano, WL; McDowell, RS; Allen, DA; Erlanson, DA; Gordon, EM; O'Brien, T Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem45:5005-22 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Caspase-5
Name:Caspase-5
Synonyms:CASP-5 | CASP5 | CASP5_HUMAN | Caspase 5 | Caspase-5 subunit p10 | Caspase-5 subunit p20 | ICE(rel)-III | ICH-3 protease | ICH3 | Protease ICH-3 | Protease TY | TY protease
Type:Enzyme
Mol. Mass.:49760.80
Organism:Homo sapiens (Human)
Description:P51878
Residue:434
Sequence:
MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK
KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
RATLTRDFYLFPGN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM223
Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC
Name:Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC
Synonyms:Caspase-4 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC | Caspase-5 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC
Type:Peptide
Mol. Mass.:584.05
Organism:n/a
Description:Molecular Mass of WEHD
Residue:4
Sequence:
WEHD