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TargetCaspase-8
LigandBDBM226
Substrate/CompetitorCaspase-8 Fluorometric Substrate Ac-Ile-Glu-Thr-Asp-AFC
Meas. Tech.Fluorometric Assay
pH7.4±n/a
Temperature298.15±n/a K
Ki 330±n/a nM
Citation Choong, ICLew, WLee, DPham, PBurdett, MTLam, JWWiesmann, CLuong, TNFahr, BDeLano, WLMcDowell, RSAllen, DAErlanson, DAGordon, EMO'Brien, T Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem45:5005-22 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Caspase-8
Name:Caspase-8
Synonyms:Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog
Type:Enzyme
Mol. Mass.:55373.89
Organism:Homo sapiens (Human)
Description:Q14790
Residue:479
Sequence:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM226
Caspase-8 Fluorometric Substrate Ac-Ile-Glu-Thr-Asp-AFC
Name:Caspase-8 Fluorometric Substrate Ac-Ile-Glu-Thr-Asp-AFC
Synonyms:n/a
Type:Peptide
Mol. Mass.:474.46
Organism:n/a
Description:Molecular Mass of IETD
Residue:4
Sequence:
IETD