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TargetCaspase-2
LigandBDBM219
Substrate/CompetitorCaspase-2 Fluorogenic Substrate Ac-Val-Asp-Val-Ala-Asp-AFC
Meas. Tech.Fluorometric Assay
pH7.4±n/a
Temperature298.15±n/a K
Ki 30000±n/a nM
Citation Choong, IC; Lew, W; Lee, D; Pham, P; Burdett, MT; Lam, JW; Wiesmann, C; Luong, TN; Fahr, B; DeLano, WL; McDowell, RS; Allen, DA; Erlanson, DA; Gordon, EM; O'Brien, T Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem45:5005-22 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Caspase-2
Name:Caspase-2
Synonyms:CASP-2 | CASP2 | CASP2_HUMAN | Caspase-2 subunit p12 | Caspase-2 subunit p13 | Caspase-2 subunit p18 | ICH-1 protease | ICH-1L/1S | ICH1 | NEDD-2 | NEDD2 | Neural precursor cell expressed developmentally down-regulated protein 2
Type:Enzyme
Mol. Mass.:50688.29
Organism:Homo sapiens (Human)
Description:P42575
Residue:452
Sequence:
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL
LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT
TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT
PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV
HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF
DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT
RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY
APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM219
Caspase-2 Fluorogenic Substrate Ac-Val-Asp-Val-Ala-Asp-AFC
Name:Caspase-2 Fluorogenic Substrate Ac-Val-Asp-Val-Ala-Asp-AFC
Synonyms:Ac-Val-Asp-Val-Ala-Asp-AFC | VDVAD
Type:Peptide
Mol. Mass.:515.51
Organism:n/a
Description:Molecular Mass of VDVAD
Residue:5
Sequence:
VDVAD