| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phosphodiesterase |
|---|
| Ligand | BDBM384821 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PDE2 Assay B |
|---|
| Ki | 0.110±n/a nM |
|---|
| Citation |  Shen, D; Wang, D; Qian, X; Harper, B; Yang, M; Bo, Y Pyrimidinone amide compounds as PDE2 inhibitors US Patent US10285989 Publication Date 5/14/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phosphodiesterase |
|---|
| Name: | Phosphodiesterase |
|---|
| Synonyms: | PDE2A3 | Phosphodiesterase A3 (PDE2A3) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 105547.91 |
|---|
| Organism: | Macaca mulatta (Rhesus macaque) |
|---|
| Description: | n/a |
|---|
| Residue: | 941 |
|---|
| Sequence: | MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCN
GLGLSDLPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQALQQRRPSEAPQAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
QDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
|
|
|
|---|
| BDBM384821 |
|---|
| n/a |
|---|
| Name | BDBM384821 |
|---|
| Synonyms: | 2-(dimethylamino)-N-{(1R)-1-[2- fluoro-4-(trifluoromethyl)phenyl]-2,2- dimethylpropyl}-6-oxo-1,6- dihydropyrimidine-4-carboxamide | US10285989, Example 37 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22F4N4O2 |
|---|
| Mol. Mass. | 414.3972 |
|---|
| SMILES | CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(cc1F)C(F)(F)F)C(C)(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
