Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM25987 |
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Substrate/Competitor | BDBM25978 |
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Meas. Tech. | Fluorescence Polarization Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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Ki | 40±n/a nM |
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IC50 | 280±n/a nM |
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Citation | Angell, RM; Angell, TD; Bamborough, P; Brown, D; Brown, M; Buckton, JB; Cockerill, SG; Edwards, CD; Jones, KL; Longstaff, T; Smee, PA; Smith, KJ; Somers, DO; Walker, AL; Willson, M Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR. Bioorg Med Chem Lett18:324-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM25987 |
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BDBM25978 |
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Name | BDBM25987 |
Synonyms: | N-[(4-methanesulfonamidophenyl)methyl]-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide | benzyl amide analog., 8 |
Type | Small organic molecule |
Emp. Form. | C25H24N4O4S |
Mol. Mass. | 476.547 |
SMILES | Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCc1ccc(NS(C)(=O)=O)cc1 |
Structure |
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