| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 1 |
|---|
| Ligand | BDBM385076 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescence Assay A2 for Recombinant Human (RH) DPP1 |
|---|
| IC50 | 5.01±n/a nM |
|---|
| Citation |  Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Pontén, JF; Doyle, KJ; Van De Poël, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors US Patent US10287258 Publication Date 5/14/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dipeptidyl peptidase 1 |
|---|
| Name: | Dipeptidyl peptidase 1 |
|---|
| Synonyms: | CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51857.28 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P53634 |
|---|
| Residue: | 463 |
|---|
| Sequence: | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
|
|
|
|---|
| BDBM385076 |
|---|
| n/a |
|---|
| Name | BDBM385076 |
|---|
| Synonyms: | BDBM445984 | US10287258, Example 36 | US11667615, Example 36 | US11680049, Example 36 | US20230278969, Example 36 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H28N3O3 |
|---|
| Mol. Mass. | 358.4541 |
|---|
| SMILES | CC[C@H](NC(=O)[C@@H]1C[NH2+]CCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
