| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-1 |
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| Ligand | BDBM10246 |
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| Substrate/Competitor | Caspase-7 Fluorometric Substrate Ac-Asp-Glu-Val-Asp-AFC |
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| Meas. Tech. | Fluorometric Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 18±n/a nM |
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| Citation |  Garcia-Calvo, M; Peterson, EP; Leiting, B; Ruel, R; Nicholson, DW; Thornberry, NA Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem273:32608-13 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Caspase-1 |
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| Name: | Caspase-1 |
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| Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
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| Type: | Enzyme |
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| Mol. Mass.: | 45154.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29466 |
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| Residue: | 404 |
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| Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
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| BDBM10246 |
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| Caspase-7 Fluorometric Substrate Ac-Asp-Glu-Val-Asp-AFC |
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| Name: | Caspase-7 Fluorometric Substrate Ac-Asp-Glu-Val-Asp-AFC |
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| Synonyms: | Ac-DEVD-AFC | Ac-DEVD-AMC | Fluorometric Tetrapeptide Ac-DEVD-AMC |
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| Type: | Peptide |
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| Mol. Mass.: | 473.41 |
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| Organism: | n/a |
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| Description: | Molecular Mass of DEVD |
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| Residue: | 4 |
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| Sequence: | |
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