Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetEpidermal growth factor receptor [696-1022,G719S]
LigandBDBM5447
Substrate/CompetitorBDBM10852
Meas. Tech.Fluorescence Binding Assay
pH7.4±n/a
Temperature295.15±n/a K
Kd 123.6±5.9 nM
Citation Yun, CHBoggon, TJLi, YWoo, MSGreulich, HMeyerson, MEck, MJ Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell11:217-27 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Epidermal growth factor receptor [696-1022,G719S]
Name:Epidermal growth factor receptor [696-1022,G719S]
Synonyms:EGF-R Tyrosine Kinase Mutant (G719S) | EGFR | EGFR_HUMAN | ERBB | ERBB1 | HER1
Type:Tyrosine-protein kinase
Mol. Mass.:37282.74
Organism:Homo sapiens (Human)
Description:P00533[696-1022,G719S]
Residue:327
Sequence:
GEAPNQALLRILKETEFKKIKVLSSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA
NKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLL
NWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK
VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ
PPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDS
NFYRALMDEEDMDDVVDADEYLIPQQG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM5447
BDBM10852
NameBDBM5447
Synonyms:CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine | US10106508, Gefitinib | US10507209, Compound Gefitinib | US9416123, Gefitinib | US9730934, Gefitinib | US9783524, Gefitinib | WO2022090481, Example gefitinib | ZD1839 | cid_123631
TypeSmall organic molecule
Emp. Form.C22H24ClFN4O3
Mol. Mass.446.902
SMILESCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: