Reaction Details |
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Target | Proto-oncogene tyrosine-protein kinase LCK |
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Ligand | BDBM26145 |
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Substrate/Competitor | Biotinylated Peptide Substrate |
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Meas. Tech. | Time Resolved Fluorescence Resonance Energy Transfer Assay |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 13±n/a nM |
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Citation | Bamborough, P; Angell, RM; Bhamra, I; Brown, D; Bull, J; Christopher, JA; Cooper, AW; Fazal, LH; Giordano, I; Hind, L; Patel, VK; Ranshaw, LE; Sims, MJ; Skone, PA; Smith, KJ; Vickerstaff, E; Washington, M N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett17:4363-8 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Proto-oncogene tyrosine-protein kinase LCK |
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Name: | Proto-oncogene tyrosine-protein kinase LCK |
Synonyms: | LCK_MOUSE | LSK | Lck | Lsk-t | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | Tyrosine-protein kinase LCK | p56-LCK |
Type: | PROTEIN |
Mol. Mass.: | 57927.84 |
Organism: | Mus musculus |
Description: | ChEMBL_806408 |
Residue: | 509 |
Sequence: | MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKER
PEDRPTFDYLRSVLDDFFTATEGQYQPQP
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BDBM26145 |
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Biotinylated Peptide Substrate |
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Name: | Biotinylated Peptide Substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 1622.70 |
Organism: | n/a |
Description: | n/a |
Residue: | 13 |
Sequence: | |