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TargetBaculoviral IAP repeat-containing protein 2 [253-363]
LigandBDBM26207
Substrate/CompetitorSmac-derived peptide
Meas. Tech.Fluorescence Polarization Assay
pH7.5±n/a
Temperature295.15±n/a K
Ki 1.1±0.5 nM
Citation Zhang, BNikolovska-Coleska, ZZhang, YBai, LQiu, SYang, CYSun, HWang, SWu, Y Design, Synthesis, and Evaluation of Tricyclic, Conformationally Constrained Small-Molecule Mimetics of Second Mitochondria-Derived Activator of Caspases. J Med Chem51:7352-5 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Baculoviral IAP repeat-containing protein 2 [253-363]
Name:Baculoviral IAP repeat-containing protein 2 [253-363]
Synonyms:API1 | BIRC2 | BIRC2_HUMAN | Baculoviral IAP repeat-containing protein 2 | HIAP-2 | IAP homolog B | Inhibitor of apoptosis protein 2 | MIHB | RING finger protein 48 | RNF48 | TNFR2-TRAF-signaling complex protein 2 | cIAP-1 BIR3
Type:BIR3 domain
Mol. Mass.:12929.05
Organism:Homo sapiens (Human)
Description:Human cIAP1 BIR3 domain (residues 253-363) was used in binding assays.
Residue:111
Sequence:
SLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGG
LRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM26207
Smac-derived peptide
Name:Smac-derived peptide
Synonyms:SM5F
Type:fluorescently labelled peptide
Mol. Mass.:1220.95
Organism:n/a
Description:5-carboxyfluorescein was coupled to the lysine side chain of the mutated Smac peptide.
Residue:10
Sequence:
AbuRPF-K(5-Fam)-NH2