Reaction Details |
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Target | Histamine H4 receptor |
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Ligand | BDBM26226 |
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Substrate/Competitor | BDBM7966 |
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Meas. Tech. | Radioligand Binding Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Ki | 3.4±n/a nM |
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Citation | Liu, H; Altenbach, RJ; Carr, TL; Chandran, P; Hsieh, GC; Lewis, LG; Manelli, AM; Milicic, I; Marsh, KC; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG; Honore, P; Esbenshade, TA; Brioni, JD; Cowart, MD cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), A New Histamine H4R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia. J Med Chem51:7094-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Histamine H4 receptor |
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Name: | Histamine H4 receptor |
Synonyms: | HH4R | HRH4_RAT | Hrh4 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44045.07 |
Organism: | Rattus norvegicus (rat) |
Description: | Cell pellets from SK-N-MC cells transfected with rat H4 receptor were used in binding assay. |
Residue: | 391 |
Sequence: | MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAIS
DFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAV
RYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAIT
AFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSL
PGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRG
RKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLY
PLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
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BDBM26226 |
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BDBM7966 |
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Name | BDBM26226 |
Synonyms: | (12S,17S)-6-(piperazin-1-yl)-11-oxa-3,5-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]heptadeca-1(10),2(7),3,5-tetraen-4-amine | A-987306 |
Type | Small organic molecule |
Emp. Form. | C18H25N5O |
Mol. Mass. | 327.424 |
SMILES | [H][C@]12CCCC[C@@]1([H])C1=C(CCc3c(nc(N)nc13)N1CCNCC1)O2 |r,t:9| |
Structure |
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