| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member C2 |
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| Ligand | BDBM26269 |
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| Substrate/Competitor | BDBM26271 |
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| Meas. Tech. | Assay of Enzyme Activity |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 70±2 nM |
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| Citation |  Dhagat, U; Endo, S; Sumii, R; Hara, A; El-Kabbani, O Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid. J Med Chem51:4844-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Aldo-keto reductase family 1 member C2 |
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| Name: | Aldo-keto reductase family 1 member C2 |
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| Synonyms: | 3-alpha-HSD3 | 3-alpha-Hydroxysteroid Dehydrogenase Type 3 (AKR1C2) | AK1C2_HUMAN | AKR1C2 | Aldo-keto reductase family 1 member C2 (AK1C2) | Aldo-keto reductase family 1 member C2 (AK1C2a) | Aldo-keto reductase family 1 member C2 (AKR1C2) | Chlordecone reductase homolog HAKRD | DD-2 | DD/BABP | DDH2 | Dihydrodiol dehydrogenase 2 | Dihydrodiol dehydrogenase/bile acid-binding protein | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | Type III 3-alpha-hydroxysteroid dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 36739.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 323 |
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| Sequence: | MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY
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| BDBM26269 |
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| BDBM26271 |
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| Name | BDBM26269 |
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| Synonyms: | 3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichlorosalicylic acid | CHEMBL449129 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H4Cl2O3 |
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| Mol. Mass. | 207.011 |
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| SMILES | OC(=O)c1cc(Cl)cc(Cl)c1O |
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| Structure | 
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