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TargetAurora kinase B
LigandBDBM26293
Substrate/CompetitorBiotinylated Peptide Substrate
Meas. Tech.Aurora B Kinase Inhibition Assay
pH7.5±n/a
Temperature295.15±n/a K
Ki 2±n/a nM
Citation Mortlock, AA; Foote, KM; Heron, NM; Jung, FH; Pasquet, G; Lohmann, JJ; Warin, N; Renaud, F; De Savi, C; Roberts, NJ; Johnson, T; Dousson, CB; Hill, GB; Perkins, D; Hatter, G; Wilkinson, RW; Wedge, SR; Heaton, SP; Odedra, R; Keen, NJ; Crafter, C; Brown, E; Thompson, K; Brightwell, S; Khatri, L; Brady, MC; Kearney, S; McKillop, D; Rhead, S; Parry, T; Green, S Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase. J Med Chem50:2213-24 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Aurora kinase B
Name:Aurora kinase B
Synonyms:AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:Protein
Mol. Mass.:39327.72
Organism:Homo sapiens (Human)
Description:Q96GD4
Residue:344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM26293
Biotinylated Peptide Substrate
Name:Biotinylated Peptide Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:2374.22
Organism:n/a
Description:n/a
Residue:20
Sequence:
biotinyl-Ahx-tetra(LRRWSLG)