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TargetAurora kinase A
LigandBDBM26314
Substrate/CompetitorFAM-PKAtide
Meas. Tech.Aurora Kinase Assay
pH7.2±n/a
Temperature294.15±n/a K
IC50 250±n/a nM
Citation Oslob, JD; Romanowski, MJ; Allen, DA; Baskaran, S; Bui, M; Elling, RA; Flanagan, WM; Fung, AD; Hanan, EJ; Harris, S; Heumann, SA; Hoch, U; Jacobs, JW; Lam, J; Lawrence, CE; McDowell, RS; Nannini, MA; Shen, W; Silverman, JA; Sopko, MM; Tangonan, BT; Teague, J; Yoburn, JC; Yu, CH; Zhong, M; Zimmerman, KM; O'Brien, T; Lew, W Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett18:4880-4 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Aurora kinase A
Name:Aurora kinase A
Synonyms:AURKA_MOUSE | Aik | Airk1 | Ark1 | Aura | Aurka | Aurora Kinase A (Aurora-A) | Aurora kinase A | Aurora-family kinase 1 | Aurora/IPL1-related kinase 1 | Ayk1 | Btak | Iak1 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase Aurora-A | Serine/threonine-protein kinase Ayk1 | Stk15 | Stk6
Type:Enzyme
Mol. Mass.:44791.66
Organism:Mus musculus (mouse)
Description:n/a
Residue:395
Sequence:
MDRCKENCVSRPVKTTVPFGPKRVLVTEQIPSQNLGSASSGQAQRVLCPSNSQRVPSQAQ
KLGAGQKPAPKQLPAASVPRPVSRLNNPQKNEQPAASGNDSEKEQASLQKTEDTKKRQWT
LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLR
HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS
KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLDYLPPEMIEGRMHDEK
VDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNAS
QRLTLAEVLEHPWIKANSSKPPTGHTSKEPTSKSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM26314
FAM-PKAtide
Name:FAM-PKAtide
Synonyms:n/a
Type:fluorescien-labeled peptide
Mol. Mass.:1620.33
Organism:n/a
Description:n/a
Residue:14
Sequence:
5FAM-GRTGRRNSI-NH2