Reaction Details |
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Target | Aurora kinase A |
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Ligand | BDBM26331 |
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Substrate/Competitor | FAM-PKAtide |
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Meas. Tech. | Aurora Kinase Assay |
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pH | 7.2±n/a |
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Temperature | 294.15±n/a K |
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IC50 | 30±n/a nM |
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Citation | Oslob, JD; Romanowski, MJ; Allen, DA; Baskaran, S; Bui, M; Elling, RA; Flanagan, WM; Fung, AD; Hanan, EJ; Harris, S; Heumann, SA; Hoch, U; Jacobs, JW; Lam, J; Lawrence, CE; McDowell, RS; Nannini, MA; Shen, W; Silverman, JA; Sopko, MM; Tangonan, BT; Teague, J; Yoburn, JC; Yu, CH; Zhong, M; Zimmerman, KM; O'Brien, T; Lew, W Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett18:4880-4 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Aurora kinase A |
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Name: | Aurora kinase A |
Synonyms: | AURKA_MOUSE | Aik | Airk1 | Ark1 | Aura | Aurka | Aurora Kinase A (Aurora-A) | Aurora kinase A | Aurora-family kinase 1 | Aurora/IPL1-related kinase 1 | Ayk1 | Btak | Iak1 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase Aurora-A | Serine/threonine-protein kinase Ayk1 | Stk15 | Stk6 |
Type: | Enzyme |
Mol. Mass.: | 44791.66 |
Organism: | Mus musculus (mouse) |
Description: | n/a |
Residue: | 395 |
Sequence: | MDRCKENCVSRPVKTTVPFGPKRVLVTEQIPSQNLGSASSGQAQRVLCPSNSQRVPSQAQ
KLGAGQKPAPKQLPAASVPRPVSRLNNPQKNEQPAASGNDSEKEQASLQKTEDTKKRQWT
LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLR
HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS
KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLDYLPPEMIEGRMHDEK
VDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNAS
QRLTLAEVLEHPWIKANSSKPPTGHTSKEPTSKSS
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BDBM26331 |
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FAM-PKAtide |
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Name: | FAM-PKAtide |
Synonyms: | n/a |
Type: | fluorescien-labeled peptide |
Mol. Mass.: | 1620.33 |
Organism: | n/a |
Description: | n/a |
Residue: | 14 |
Sequence: | |