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TargetUDP-N-acetylmuramoylalanine--D-glutamate ligase
LigandBDBM26454
Substrate/CompetitorBDBM26431
Meas. Tech.MurD Inhibition Assay
pH8.6±n/a
Temperature310.15±n/a K
IC50 100000±n/a nM
Citation Humljan, JKotnik, MContreras-Martel, CBlanot, DUrleb, UDessen, ASolmajer, TGobec, S Novel Naphthalene-N-sulfonyl-d-glutamic Acid Derivatives as Inhibitors of MurD, a Key Peptidoglycan Biosynthesis Enzyme. J Med Chem51:7486-94 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Name:UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms:D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD
Type:Ligase
Mol. Mass.:46963.02
Organism:Escherichia coli (strain K12)
Description:n/a
Residue:438
Sequence:
MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLND
EWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVT
TLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNV
TEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHL
NHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGL
PHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYL
NGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQF
KNFEQRGNEFARLAKELG
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  Blast E-value cutoff:
BDBM26454
BDBM26431
NameBDBM26454
Synonyms:(2R)-2-({6-[(4-cyano-2-methoxyphenyl)methoxy]naphthalene-2-}sulfonamido)pentanedioic acid | naphthalene-N-sulfonyl-D-glu derivative, 17m
TypeSmall organic molecule
Emp. Form.C24H22N2O8S
Mol. Mass.498.505
SMILESCOc1cc(ccc1COc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H](CCC(O)=O)C(O)=O)C#N |r|
Structure
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