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TargetDNA-(apurinic or apyrimidinic site) endonuclease
LigandBDBM26582
Substrate/CompetitorDNA Substrate
Meas. Tech.APE1 Inhibition Assay
pH7.5±n/a
Temperature303.15±n/a K
IC50 16000±4000 nM
Citation Zawahir, ZDayam, RDeng, JPereira, CNeamati, N Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem52:20-32 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
DNA-(apurinic or apyrimidinic site) endonuclease
Name:DNA-(apurinic or apyrimidinic site) endonuclease
Synonyms:APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1
Type:Protein
Mol. Mass.:35560.12
Organism:Homo sapiens (Human)
Description:P27695
Residue:318
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA
TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS
APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV
RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI
RSKALGSDHCPITLYLAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM26582
DNA Substrate
Name:DNA Substrate
Synonyms:Annealed double-stranded oligonucleotide with an abasic site
Type:Radiolabeled substrate
Mol. Mass.:2306.64
Organism:n/a
Description:The top strand is 5-ATTTCACCGGTACG(F)TCTAGAATCC-3 containing the tetrahydrofuran synthetic abasic residue (F). It is radiolabeled with gamma-32P.
Residue:26
Sequence:
5 -ATTTCACCGGTACG(F)TCTAGAATCCG-3