Reaction Details |
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Target | DNA-(apurinic or apyrimidinic site) endonuclease |
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Ligand | BDBM26589 |
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Substrate/Competitor | DNA Substrate |
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Meas. Tech. | APE1 Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 303.15±n/a K |
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IC50 | 20000±n/a nM |
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Citation | Zawahir, Z; Dayam, R; Deng, J; Pereira, C; Neamati, N Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem52:20-32 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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DNA-(apurinic or apyrimidinic site) endonuclease |
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Name: | DNA-(apurinic or apyrimidinic site) endonuclease |
Synonyms: | APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1 |
Type: | Protein |
Mol. Mass.: | 35560.12 |
Organism: | Homo sapiens (Human) |
Description: | P27695 |
Residue: | 318 |
Sequence: | MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA
TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS
APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV
RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI
RSKALGSDHCPITLYLAL
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BDBM26589 |
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DNA Substrate |
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Name: | DNA Substrate |
Synonyms: | Annealed double-stranded oligonucleotide with an abasic site |
Type: | Radiolabeled substrate |
Mol. Mass.: | 2306.64 |
Organism: | n/a |
Description: | The top strand is 5-ATTTCACCGGTACG(F)TCTAGAATCC-3 containing the tetrahydrofuran synthetic abasic residue (F). It is radiolabeled with gamma-32P. |
Residue: | 26 |
Sequence: | 5 -ATTTCACCGGTACG(F)TCTAGAATCCG-3
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