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TargetSerine/threonine-protein kinase pim-1
LigandBDBM26699
Substrate/CompetitorBiotinylated Substrate Peptide
Meas. Tech.Pim Kinase Assay
pH7.5±n/a
Temperature295.15±n/a K
Ki 15.0±n/a nM
Citation Tong, YStewart, KDThomas, SPrzytulinska, MJohnson, EFKlinghofer, VLeverson, JMcCall, OSoni, NBLuo, YLin, NHSowin, TJGiranda, VLPenning, TD Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling. Bioorg Med Chem Lett18:5206-8 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Serine/threonine-protein kinase pim-1
Name:Serine/threonine-protein kinase pim-1
Synonyms:PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:Protein
Mol. Mass.:35681.82
Organism:Homo sapiens (Human)
Description:P11309
Residue:313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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  Blast E-value cutoff:
BDBM26699
Biotinylated Substrate Peptide
Name:Ryanodine receptor 1 [4317-4329]
Synonyms:Biotinylated Substrate Peptide | RYDR | RYR1 | RYR1_HUMAN
Type:Peptide
Mol. Mass.:2871.44
Organism:n/a
Description:P21817[4317-4329]
Residue:24
Sequence:
biotin-C6linker-VRRLRRLTAREAA