Reaction Details |
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Target | Serine/threonine-protein kinase pim-1 |
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Ligand | BDBM26699 |
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Substrate/Competitor | Biotinylated Substrate Peptide |
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Meas. Tech. | Pim Kinase Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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Ki | 15.0±n/a nM |
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Citation | Tong, Y; Stewart, KD; Thomas, S; Przytulinska, M; Johnson, EF; Klinghofer, V; Leverson, J; McCall, O; Soni, NB; Luo, Y; Lin, NH; Sowin, TJ; Giranda, VL; Penning, TD Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling. Bioorg Med Chem Lett18:5206-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Serine/threonine-protein kinase pim-1 |
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Name: | Serine/threonine-protein kinase pim-1 |
Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
Type: | Protein |
Mol. Mass.: | 35681.82 |
Organism: | Homo sapiens (Human) |
Description: | P11309 |
Residue: | 313 |
Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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BDBM26699 |
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Biotinylated Substrate Peptide |
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Name: | Ryanodine receptor 1 [4317-4329] |
Synonyms: | Biotinylated Substrate Peptide | RYDR | RYR1 | RYR1_HUMAN |
Type: | Peptide |
Mol. Mass.: | 2871.44 |
Organism: | n/a |
Description: | P21817[4317-4329] |
Residue: | 24 |
Sequence: | biotin-C6linker-VRRLRRLTAREAA
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