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TargetSerine/threonine-protein kinase pim-2
LigandBDBM26697
Substrate/CompetitorBiotinylated Substrate Peptide
Meas. Tech.Pim Kinase Assay
pH7.5±n/a
Temperature295.15±n/a K
Ki 174±n/a nM
Citation Tong, Y; Stewart, KD; Thomas, S; Przytulinska, M; Johnson, EF; Klinghofer, V; Leverson, J; McCall, O; Soni, NB; Luo, Y; Lin, NH; Sowin, TJ; Giranda, VL; Penning, TD Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling. Bioorg Med Chem Lett18:5206-8 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Serine/threonine-protein kinase pim-2
Name:Serine/threonine-protein kinase pim-2
Synonyms:PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:Serine/threonine-protein kinase
Mol. Mass.:34185.93
Organism:Homo sapiens (Human)
Description:Q9P1W9
Residue:311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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  Blast E-value cutoff:
BDBM26697
Biotinylated Substrate Peptide
Name:Ryanodine receptor 1 [4317-4329]
Synonyms:Biotinylated Substrate Peptide | RYDR | RYR1 | RYR1_HUMAN
Type:Peptide
Mol. Mass.:2871.44
Organism:n/a
Description:P21817[4317-4329]
Residue:24
Sequence:
biotin-C6linker-VRRLRRLTAREAA