| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM26736 |
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| Substrate/Competitor | BDBM26737 |
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| Meas. Tech. | Serine Hydrolase Activity Assay |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 5.3±n/a nM |
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| Citation |  Alexander, JP; Cravatt, BF The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. J Am Chem Soc128:9699-704 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33391.67 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells. |
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| Residue: | 303 |
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| Sequence: | MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLG
HSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRID
SSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAG
CPP
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| BDBM26736 |
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| BDBM26737 |
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| Name | BDBM26736 |
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| Synonyms: | CHEMBL509860 | LY2183240 | N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1H-1,2,3,4-tetrazole-1-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N5O |
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| Mol. Mass. | 307.3498 |
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| SMILES | CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1ccccc1 |
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| Structure | 
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