Reaction Details |
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Target | Fatty-acid amide hydrolase 1 |
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Ligand | BDBM26741 |
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Substrate/Competitor | BDBM23028 |
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Meas. Tech. | FAAH Inhibition Assay (30 min Preincubation) |
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pH | 7.4±n/a |
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Temperature | 303.15±n/a K |
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IC50 | 473±n/a nM |
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Comments | time-dependent inhibition. |
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Citation | Ahn, K; Johnson, DS; Fitzgerald, LR; Liimatta, M; Arendse, A; Stevenson, T; Lund, ET; Nugent, RA; Nomanbhoy, TK; Alexander, JP; Cravatt, BF Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry46:13019-30 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Fatty-acid amide hydrolase 1 |
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Name: | Fatty-acid amide hydrolase 1 |
Synonyms: | Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1 |
Type: | Protein |
Mol. Mass.: | 63071.19 |
Organism: | Homo sapiens (Human) |
Description: | O00519 |
Residue: | 579 |
Sequence: | MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQ
RFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLAD
CETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAV
PFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGG
SIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCE
DMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTL
VPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAF
LVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALD
LNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMK
KSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
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BDBM26741 |
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BDBM23028 |
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Name | BDBM26741 |
Synonyms: | N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide | PF-622 | US9169224, 19 |
Type | Small organic molecule |
Emp. Form. | C21H22N4O |
Mol. Mass. | 346.4256 |
SMILES | O=C(Nc1ccccc1)N1CCN(Cc2ccc3ccccc3n2)CC1 |
Structure |
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