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TargetFatty-acid amide hydrolase 1
LigandBDBM26740
Substrate/CompetitorBDBM23028
Meas. Tech.FAAH Inhibition Assay (60 min Preincubation)
pH7.4±n/a
Temperature303.15±n/a K
IC50 16.2±n/a nM
Commentstime-dependent inhibition.
Citation Ahn KJohnson DSFitzgerald LRLiimatta MArendse AStevenson TLund ETNugent RANomanbhoy TKAlexander JPCravatt BF Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry 46:13019-30 (2007) [PubMed]  Article
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Fatty-acid amide hydrolase 1
Name:Fatty-acid amide hydrolase 1
Synonyms:Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Oleamide hydrolase 1
Type:Protein
Mol. Mass.:63071.19
Organism:Homo sapiens (Human)
Description:O00519
Residue:579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQ
RFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLAD
CETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAV
PFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGG
SIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCE
DMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTL
VPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAF
LVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALD
LNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMK
KSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
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BDBM26740
BDBM23028
NameBDBM26740
Synonyms:N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide | PF-750
TypeSmall organic molecule
Emp. Form.C22H23N3O
Mol. Mass.345.4375
SMILESO=C(Nc1ccccc1)N1CCC(Cc2cnc3ccccc3c2)CC1
Structure
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