| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor |
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| Ligand | BDBM65497 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | cytomteric bead array (CBA) assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 0.59±n/a nM |
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| Comments | extracted |
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| Citation |  Gandhi, A; Dimartino, J; Chopra, R Methods for the treatment of locally advanced breast cancer US Patent US9694015 Publication Date 7/4/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tumor necrosis factor |
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| Name: | Tumor necrosis factor |
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| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 25645.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01375 |
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| Residue: | 233 |
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| Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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|
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| BDBM65497 |
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| n/a |
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| Name | BDBM65497 |
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| Synonyms: | CC-220 (Compound 6) | US9694015, 6.4S |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N3O5 |
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| Mol. Mass. | 449.499 |
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| SMILES | O=C1N(Cc2c1cccc2OCc1ccc(CN2CCOCC2)cc1)[C@H]1CCC(=O)NC1=O |
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| Structure | 
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