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TargetVitamin D3 receptor
LigandBDBM263412
Substrate/Competitorn/a
Meas. Tech.Dopamine D3 Receptor Binding Test
Ki 0.093±n/a nM
Citation Li JChen XMa ZZhang LCui N Benzoisothiazole compounds and methods of treating schizophrenia US Patent  US9550741 Publication Date 1/24/2017
More Info.:Get all data from this article,  Assay Method
 
Vitamin D3 receptor
Name:Vitamin D3 receptor
Synonyms:1,25-dihydroxyvitamin D3 receptor | Nuclear receptor subfamily 1 group I member 1 | VDR
Type:Protein
Mol. Mass.:48288.72
Organism:Homo sapiens (Human)
Description:P11473
Residue:427
Sequence:
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
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  Blast E-value cutoff:
BDBM263412
n/a
NameBDBM263412
Synonyms:US9550741, II-17
TypeSmall organic molecule
Emp. Form.C23H31N5O2S2
Mol. Mass.473.655
SMILESO=S(=O)(N[C@@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1ccc[nH]1 |r,wU:4.3,7.7,(-7.08,.38,;-7.08,1.92,;-7.08,3.46,;-5.75,2.69,;-4.41,1.92,;-4.41,.38,;-3.08,-.39,;-1.75,.38,;-.41,-.39,;.92,.38,;2.26,-.39,;2.26,-1.93,;3.59,-2.7,;4.92,-1.93,;4.92,-.39,;3.59,.38,;6.26,-2.7,;6.26,-4.24,;7.72,-4.71,;8.63,-3.47,;10.16,-3.3,;10.78,-1.9,;9.88,-.65,;8.35,-.81,;7.72,-2.22,;-1.75,1.92,;-3.08,2.7,;-8.41,2.69,;-8.41,4.23,;-9.88,4.71,;-10.78,3.46,;-9.88,2.22,)|
Structure
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