Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCarbonic anhydrase 15 [19-324]
LigandBDBM10868
Substrate/CompetitorBDBM10856
Meas. Tech.CA Inhibition Assay
pH7.5±n/a
Temperature293.15±n/a K
Ki 48±n/a nM
Citation Hilvo, MSalzano, AMInnocenti, AKulomaa, MSScozzafava, AScaloni, AParkkila, SSupuran, CT Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem52:646-54 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Carbonic anhydrase 15 [19-324]
Name:Carbonic anhydrase 15 [19-324]
Synonyms:CA-XV | CAH15_MOUSE | Ca15 | Car15 | Carbonate dehydratase XV | Carbonic Anhydrase XV
Type:Enzyme
Mol. Mass.:33409.51
Organism:Mus musculus (mouse)
Description:Mouse cloned isozyme.
Residue:306
Sequence:
VDSSGTWCYDSQDPKCGPAHWKELAPACGGPTQSPINIDLRLVQRDYTLKPFIFQGYDSA
PQDPWVLENDGHTVLLRVNSCQQNCPAIRGAGLPSPEYRLLQLHFHWGSPGHQGSEHSLD
EKHGSMEMHMVHMNTKYQSMEDARSQPDGFAILAVLLVEEDRDNTNFSAIVSGLKNLSSP
GVAVNLTSTFALASLLPSALRLLRYYRYSGSLTTPGCEPAVLWTVFENTVPIGHAQVVQF
QAVLQTGPPGLHPRPLTSNFRPQQPLGGRRISASPEASVRSSVSTLPCLHLALVGLGVGL
RLWQGP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM10868
BDBM10856
NameBDBM10868
Synonyms:1,3,4-Thiadiazole-2-sulfonamide, 6 | 1,3,4-thiadiazole-2-sulfonamide 15 | 5-Amino-1,3,4-thiadiazole-2-sulphonamide (1) | 5-amino-1,3,4-thiadiazole-2-sulfonamide | CHEMBL265674 | aromatic/heteroaromatic sulfonamide 13
TypeSmall organic molecule
Emp. Form.C2H4N4O2S2
Mol. Mass.180.209
SMILESNc1nnc(s1)S(N)(=O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: