| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 15 [19-324] |
|---|
| Ligand | BDBM10884 |
|---|
| Substrate/Competitor | BDBM10856 |
|---|
| Meas. Tech. | CA Inhibition Assay |
|---|
| Ki | 61±n/a nM |
|---|
| Citation |  Hilvo, M; Salzano, AM; Innocenti, A; Kulomaa, MS; Scozzafava, A; Scaloni, A; Parkkila, S; Supuran, CT Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem52:646-54 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Carbonic anhydrase 15 [19-324] |
|---|
| Name: | Carbonic anhydrase 15 [19-324] |
|---|
| Synonyms: | CA-XV | CAH15_MOUSE | Ca15 | Car15 | Carbonate dehydratase XV | Carbonic Anhydrase XV |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 33409.51 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | Mouse cloned isozyme. |
|---|
| Residue: | 306 |
|---|
| Sequence: | VDSSGTWCYDSQDPKCGPAHWKELAPACGGPTQSPINIDLRLVQRDYTLKPFIFQGYDSA
PQDPWVLENDGHTVLLRVNSCQQNCPAIRGAGLPSPEYRLLQLHFHWGSPGHQGSEHSLD
EKHGSMEMHMVHMNTKYQSMEDARSQPDGFAILAVLLVEEDRDNTNFSAIVSGLKNLSSP
GVAVNLTSTFALASLLPSALRLLRYYRYSGSLTTPGCEPAVLWTVFENTVPIGHAQVVQF
QAVLQTGPPGLHPRPLTSNFRPQQPLGGRRISASPEASVRSSVSTLPCLHLALVGLGVGL
RLWQGP
|
|
|
|---|
| BDBM10884 |
|---|
| BDBM10856 |
|---|
| Name | BDBM10884 |
|---|
| Synonyms: | (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide | Dorzolamide (DRZ) | Dorzolamide (DZA) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H16N2O4S3 |
|---|
| Mol. Mass. | 324.44 |
|---|
| SMILES | CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
