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TargetOxysterols receptor LXR-alpha
LigandBDBM19992
Substrate/Competitorbiotinylated SRC-1 peptide
Meas. Tech.Fluorescence Resonance Energy Transfer (FRET) Ligand Sensing Assay (LiSA)
pH7.5±n/a
Temperature295.15±n/a K
EC50 175±n/a nM
Comments100% efficacy.
Citation Washburn, DG; Hoang, TH; Campobasso, N; Smallwood, A; Parks, DJ; Webb, CL; Frank, KA; Nord, M; Duraiswami, C; Evans, C; Jaye, M; Thompson, SK Synthesis and SAR of potent LXR agonists containing an indole pharmacophore. Bioorg Med Chem Lett19:1097-100 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Oxysterols receptor LXR-alpha
Name:Oxysterols receptor LXR-alpha
Synonyms:LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:Enzyme Catalytic Domain
Mol. Mass.:50403.85
Organism:Homo sapiens (Human)
Description:Q13133
Residue:447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM19992
biotinylated SRC-1 peptide
Name:biotinylated SRC-1 peptide
Synonyms:n/a
Type:Peptide
Mol. Mass.:3157.52
Organism:n/a
Description:A biotinylated peptide comprises amino acids 675-699 of steroid receptor coactivator 1 (SRC1).
Residue:28
Sequence:
CPSSHSSLTERHKILHRLLQEGSPS-CONH2