Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Histone deacetylase 1 | ||
Ligand | BDBM27180 | ||
Substrate/Competitor | BDBM25143 | ||
Meas. Tech. | HDAC Activity Assay | ||
pH | 8±n/a | ||
Temperature | 310.15±n/a K | ||
IC50 | 10.6±n/a nM | ||
Citation | Oyelere, AK; Chen, PC; Guerrant, W; Mwakwari, SC; Hood, R; Zhang, Y; Fan, Y Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem52:456-68 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Histone deacetylase 1 | |||
Name: | Histone deacetylase 1 | ||
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 55090.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q13547 | ||
Residue: | 482 | ||
Sequence: |
| ||
BDBM27180 | |||
BDBM25143 | |||
Name | BDBM27180 | ||
Synonyms: | 7-{4-[4-({[(2S,3R,4S,6R)-2-{[(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10,13-tetrahydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl]oxy}-3-hydroxy-6-methyloxan-4-yl](methyl)amino}methyl)phenyl]-1H-1,2,3-triazol-1-yl}-N-hydroxyheptanamide | triazole-linked azithromycin-based compound, 16d | ||
Type | n/a | ||
Emp. Form. | C45H76N6O11 | ||
Mol. Mass. | 877.1185 | ||
SMILES | CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)Cc2ccc(cc2)-c2cn(CCCCCCC(=O)NO)nn2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O | ||
Structure |