Ki Summary

Reaction Details

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Target

Histamine H1 receptor

Ligand

BDBM27213

Substrate/Competitor

BDBM22567

Meas. Tech.

Radioligand Binding Assay

7.4±n/a

Temperature

298.15±n/a K

>10000±n/a nM

Citation

Zhao, C; Sun, M; Bennani, YL; Gopalakrishnan, SM; Witte, DG; Miller, TR; Krueger, KM; Browman, KE; Thiffault, C; Wetter, J; Marsh, KC; Hancock, AA; Esbenshade, TA; Cowart, MD The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J Med Chem51:5423-30 (2008) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Histamine H1 receptor

Name:

Histamine H1 receptor

Synonyms:

H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

55808.72

Organism:

Homo sapiens (Human)

Description:

Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.

Residue:

487

Sequence:

MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS

BDBM27213

BDBM22567

Name

BDBM27213

Synonyms:

4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole | CHEMBL14638 | CHEMBL1795025 | Ciproxifan

Type

Small organic molecule

Emp. Form.

C16H18N2O2

Mol. Mass.

270.3263

SMILES

O=C(C1CC1)c1ccc(OCCCc2cnc[nH]2)cc1

Structure