| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H3 receptor |
|---|
| Ligand | BDBM27208 |
|---|
| Substrate/Competitor | BDBM22530 |
|---|
| Meas. Tech. | Radioligand Binding Assay |
|---|
| Ki | 0.49±n/a nM |
|---|
| Citation |  Zhao, C; Sun, M; Bennani, YL; Gopalakrishnan, SM; Witte, DG; Miller, TR; Krueger, KM; Browman, KE; Thiffault, C; Wetter, J; Marsh, KC; Hancock, AA; Esbenshade, TA; Cowart, MD The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J Med Chem51:5423-30 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Histamine H3 receptor |
|---|
| Name: | Histamine H3 receptor |
|---|
| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 48607.98 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 445 |
|---|
| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
|
|
|
|---|
| BDBM27208 |
|---|
| BDBM22530 |
|---|
| Name | BDBM27208 |
|---|
| Synonyms: | (2S,3S)-2-amino-N,3-dimethyl-N-[(1R,2S,5S,6S,9R,12S,13R,16S)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-18-en-16-yl]pentanamide | Conessine analogue, 13a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H49N3O |
|---|
| Mol. Mass. | 455.7189 |
|---|
| SMILES | [H][C@@]1(C)N(C)C[C@]23CC[C@@]4([H])[C@@]([H])(CC=C5C[C@H](CC[C@]45C)N(C)C(=O)[C@@H](N)[C@@H](C)CC)[C@]2([H])CC[C@]13[H] |r,t:14| |
|---|
| Structure | 
|
|---|
Search and Browse
