Reaction Details |
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Target | Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A |
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Ligand | BDBM27393 |
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Substrate/Competitor | MCM2 |
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Meas. Tech. | In Vitro Kinase Assay |
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pH | 7.9±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 45±12 nM |
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Citation | Vanotti, E; Amici, R; Bargiotti, A; Berthelsen, J; Bosotti, R; Ciavolella, A; Cirla, A; Cristiani, C; D'Alessio, R; Forte, B; Isacchi, A; Martina, K; Menichincheri, M; Molinari, A; Montagnoli, A; Orsini, P; Pillan, A; Roletto, F; Scolaro, A; Tibolla, M; Valsasina, B; Varasi, M; Volpi, D; Santocanale, C Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships. J Med Chem51:487-501 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A |
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Name: | Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A |
Synonyms: | Cdc7 Kinase | Cdc7/DBF4 |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cell division cycle 7-related protein kinase [58-574] |
Synonyms: | CDC7 | CDC7L1 | CDC7_HUMAN | Cdc7 Kinase | Cell division cycle 7-related protein kinase |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 57470.88 |
Organism: | Homo sapiens (Human) |
Description: | O00311[58-574] |
Residue: | 517 |
Sequence: | FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV
MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRD
VKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIP
LSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSS
ISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATD
KVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKA
SDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTS
DIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNE
VPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
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Component 2 |
Name: | Protein DBF4 homolog A |
Synonyms: | ASK | Activator of S phase kinase | Chiffon homolog A | DBF4 | DBF4-type zinc finger-containing protein 1 | DBF4A | DBF4A_HUMAN | Protein DBF4 homolog A | ZDBF1 |
Type: | Regulatory subunit |
Mol. Mass.: | 76869.65 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 674 |
Sequence: | MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTI
SEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPH
PSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIE
QKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMP
FINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCL
QKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSP
VSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPS
NELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVD
HYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQ
EHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRT
EFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLT
AFFSSPSTSTFTGF
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BDBM27393 |
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MCM2 |
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Name: | MCM2 |
Synonyms: | BM28 | CCNL1 | CDCL1 | DNA replication licensing factor MCM2 | KIAA0030 | MCM2 | MCM2_HUMAN | Minichromosome maintenance protein 2 homolog | Nuclear protein BM28 |
Type: | Other Protein Type |
Mol. Mass.: | 32619.37 |
Organism: | Homo sapiens (Human) |
Description: | P49736[10-294] |
Residue: | 285 |
Sequence: | MASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDG
EELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLG
RMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMA
GPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLP
EAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEEL
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