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TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
LigandBDBM27401
Substrate/CompetitorMCM2
Meas. Tech.In Vitro Kinase Assay
pH7.9±n/a
Temperature298.15±n/a K
IC50 3300±n/a nM
Citation Vanotti, EAmici, RBargiotti, ABerthelsen, JBosotti, RCiavolella, ACirla, ACristiani, CD'Alessio, RForte, BIsacchi, AMartina, KMenichincheri, MMolinari, AMontagnoli, AOrsini, PPillan, ARoletto, FScolaro, ATibolla, MValsasina, BVarasi, MVolpi, DSantocanale, C Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships. J Med Chem51:487-501 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
Name:Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
Synonyms:Cdc7 Kinase | Cdc7/DBF4
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Cell division cycle 7-related protein kinase [58-574]
Synonyms:CDC7 | CDC7L1 | CDC7_HUMAN | Cdc7 Kinase | Cell division cycle 7-related protein kinase
Type:Serine/threonine-protein kinase
Mol. Mass.:57470.88
Organism:Homo sapiens (Human)
Description:O00311[58-574]
Residue:517
Sequence:
FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV
MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRD
VKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIP
LSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSS
ISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATD
KVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKA
SDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTS
DIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNE
VPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
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Component 2
Name:Protein DBF4 homolog A
Synonyms:ASK | Activator of S phase kinase | Chiffon homolog A | DBF4 | DBF4-type zinc finger-containing protein 1 | DBF4A | DBF4A_HUMAN | Protein DBF4 homolog A | ZDBF1
Type:Regulatory subunit
Mol. Mass.:76869.65
Organism:Homo sapiens (Human)
Description:n/a
Residue:674
Sequence:
MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTI
SEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPH
PSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIE
QKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMP
FINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCL
QKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSP
VSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPS
NELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVD
HYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQ
EHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRT
EFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLT
AFFSSPSTSTFTGF
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BDBM27401
MCM2
Name:MCM2
Synonyms:BM28 | CCNL1 | CDCL1 | DNA replication licensing factor MCM2 | KIAA0030 | MCM2 | MCM2_HUMAN | Minichromosome maintenance protein 2 homolog | Nuclear protein BM28
Type:Other Protein Type
Mol. Mass.:32619.37
Organism:Homo sapiens (Human)
Description:P49736[10-294]
Residue:285
Sequence:
MASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDG
EELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLG
RMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMA
GPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLP
EAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEEL
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