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TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
LigandBDBM27433
Substrate/CompetitorHis6-tagged MCM2
Meas. Tech.Radioactive Kinase Assay
pH7.5±n/a
Temperature310.15±n/a K
Ki 5±n/a nM
IC50 50±n/a nM
Citation Zhao, CTovar, CYin, XXu, QTodorov, ITVassilev, LTChen, L Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors. Bioorg Med Chem Lett19:319-23 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
Name:Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
Synonyms:Cdc7 Kinase | Cdc7/DBF4
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Cell division cycle 7-related protein kinase [58-574]
Synonyms:CDC7 | CDC7L1 | CDC7_HUMAN | Cdc7 Kinase | Cell division cycle 7-related protein kinase
Type:Serine/threonine-protein kinase
Mol. Mass.:57470.88
Organism:Homo sapiens (Human)
Description:O00311[58-574]
Residue:517
Sequence:
FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV
MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRD
VKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIP
LSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSS
ISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATD
KVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKA
SDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTS
DIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNE
VPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
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Component 2
Name:Protein DBF4 homolog A
Synonyms:ASK | Activator of S phase kinase | Chiffon homolog A | DBF4 | DBF4-type zinc finger-containing protein 1 | DBF4A | DBF4A_HUMAN | Protein DBF4 homolog A | ZDBF1
Type:Regulatory subunit
Mol. Mass.:76869.65
Organism:Homo sapiens (Human)
Description:n/a
Residue:674
Sequence:
MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTI
SEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPH
PSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIE
QKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMP
FINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCL
QKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSP
VSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPS
NELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVD
HYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQ
EHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRT
EFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLT
AFFSSPSTSTFTGF
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BDBM27433
His6-tagged MCM2
Name:His6-tagged MCM2
Synonyms:BM28 | CCNL1 | CDCL1 | DNA replication licensing factor MCM2 | KIAA0030 | MCM2 | MCM2_HUMAN | Minichromosome maintenance protein 2 homolog | Nuclear protein BM28
Type:Other Protein Type
Mol. Mass.:52558.30
Organism:Homo sapiens (Human)
Description:P49736[1-467]
Residue:467
Sequence:
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTE
GPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQR
DREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGH
SVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAR
EHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQL
HLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGP
FEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHN
NYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSL
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