| Reaction Details |
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 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase 2 |
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| Ligand | BDBM27496 |
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| Substrate/Competitor | BDBM27089 |
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| Meas. Tech. | Scintillation Proximity Assay (SPA) |
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| pH | 7.8±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 4169±702 nM |
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| Citation |  Eltze, T; Boer, R; Wagner, T; Weinbrenner, S; McDonald, MC; Thiemermann, C; Bürkle, A; Klein, T Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol74:1587-98 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Poly [ADP-ribose] polymerase 2 |
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| Name: | Poly [ADP-ribose] polymerase 2 |
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| Synonyms: | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 2 | ADPRT-2 | ARTD2 | Adprt2 | Adprtl2 | Aspartl2 | DNA ADP-ribosyltransferase PARP2 | NAD(+) ADP-ribosyltransferase 2 | PARP-2 | PARP2_MOUSE | Parp2 | Poly (ADP-ribose) Polymerase-2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (Parp2) | Poly [ADP-ribose] polymerase-2 | Poly[ADP-ribose] synthase 2 | Poly[ADP-ribose] synthetase 2 | Protein poly-ADP-ribosyltransferase PARP2 | mPARP-2 | pADPRT-2 | poly-ADP-ribose polymerase 2 (PARP2) |
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| Type: | n/a |
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| Mol. Mass.: | 63409.97 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Alexis Biochemicals, Cat. no. ALX-201-064-C020 |
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| Residue: | 559 |
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| Sequence: | MAPRRQRSGSGRRVLNEAKKVDNGNKATEDDSPPGKKMRTCQRKGPMAGGKDADRTKDNR
DSVKTLLLKGKAPVDPECAAKLGKAHVYCEGDDVYDVMLNQTNLQFNNNKYYLIQLLEDD
AQRNFSVWMRWGRVGKTGQHSLVTCSGDLNKAKEIFQKKFLDKTKNNWEDRENFEKVPGK
YDMLQMDYAASTQDESKTKEEETLKPESQLDLRVQELLKLICNVQTMEEMMIEMKYDTKR
APLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEACNEFYTRIPHDFGLSIPPVIRTE
KELSDKVKLLEALGDIEIALKLVKSERQGLEHPLDQHYRNLHCALRPLDHESNEFKVISQ
YLQSTHAPTHKDYTMTLLDVFEVEKEGEKEAFREDLPNRMLLWHGSRLSNWVGILSHGLR
VAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPK
AQGLLRGKHSTKGMGKMAPSPAHFITLNGSTVPLGPASDTGILNPEGYTLNYNEFIVYSP
NQVRMRYLLKIQFNFLQLW
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| BDBM27496 |
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| BDBM27089 |
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| Name | BDBM27496 |
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| Synonyms: | (4Z)-4-[(1-methyl-1H-pyrrol-2-yl)methylidene]-1,2,3,4-tetrahydroisoquinoline-1,3-dione | (4Z)-4-[(1-methyl-1H-pyrrol-2-yl)methylidene]isoquinoline-1,3(2H,4H)-dione | BYK204165 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12N2O2 |
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| Mol. Mass. | 252.268 |
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| SMILES | Cn1cccc1\C=C1/C(=O)NC(=O)c2ccccc12 |
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| Structure | 
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