Reaction Details |
| Report a problem with these data |
Target | Poly [ADP-ribose] polymerase 2 |
---|
Ligand | BDBM27498 |
---|
Substrate/Competitor | BDBM27089 |
---|
Meas. Tech. | Scintillation Proximity Assay (SPA) |
---|
pH | 7.8±n/a |
---|
Temperature | 295.15±n/a K |
---|
IC50 | 32±3 nM |
---|
Citation | Eltze, T; Boer, R; Wagner, T; Weinbrenner, S; McDonald, MC; Thiemermann, C; Bürkle, A; Klein, T Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol74:1587-98 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Poly [ADP-ribose] polymerase 2 |
---|
Name: | Poly [ADP-ribose] polymerase 2 |
Synonyms: | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 2 | ADPRT-2 | ARTD2 | Adprt2 | Adprtl2 | Aspartl2 | DNA ADP-ribosyltransferase PARP2 | NAD(+) ADP-ribosyltransferase 2 | PARP-2 | PARP2_MOUSE | Parp2 | Poly (ADP-ribose) Polymerase-2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (Parp2) | Poly [ADP-ribose] polymerase-2 | Poly[ADP-ribose] synthase 2 | Poly[ADP-ribose] synthetase 2 | Protein poly-ADP-ribosyltransferase PARP2 | mPARP-2 | pADPRT-2 | poly-ADP-ribose polymerase 2 (PARP2) |
Type: | n/a |
Mol. Mass.: | 63409.97 |
Organism: | Mus musculus (Mouse) |
Description: | Alexis Biochemicals, Cat. no. ALX-201-064-C020 |
Residue: | 559 |
Sequence: | MAPRRQRSGSGRRVLNEAKKVDNGNKATEDDSPPGKKMRTCQRKGPMAGGKDADRTKDNR
DSVKTLLLKGKAPVDPECAAKLGKAHVYCEGDDVYDVMLNQTNLQFNNNKYYLIQLLEDD
AQRNFSVWMRWGRVGKTGQHSLVTCSGDLNKAKEIFQKKFLDKTKNNWEDRENFEKVPGK
YDMLQMDYAASTQDESKTKEEETLKPESQLDLRVQELLKLICNVQTMEEMMIEMKYDTKR
APLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEACNEFYTRIPHDFGLSIPPVIRTE
KELSDKVKLLEALGDIEIALKLVKSERQGLEHPLDQHYRNLHCALRPLDHESNEFKVISQ
YLQSTHAPTHKDYTMTLLDVFEVEKEGEKEAFREDLPNRMLLWHGSRLSNWVGILSHGLR
VAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPK
AQGLLRGKHSTKGMGKMAPSPAHFITLNGSTVPLGPASDTGILNPEGYTLNYNEFIVYSP
NQVRMRYLLKIQFNFLQLW
|
|
|
BDBM27498 |
---|
BDBM27089 |
---|
Name | BDBM27498 |
Synonyms: | 10-amino-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaene-2,4-dione | 4-ANI | 4-Amino-1,8-naphthalimide | CHEMBL338790 |
Type | Small organic molecule |
Emp. Form. | C12H8N2O2 |
Mol. Mass. | 212.2041 |
SMILES | Nc1ccc2C(=O)NC(=O)c3cccc1c23 |
Structure |
|