Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGag-Pol polyprotein [588-1027,K691N]/[588-1147,K690N]
LigandBDBM27577
Substrate/Competitorpoly r(A).oligo d(T)16
Meas. Tech.Reverse Transcriptase Assay
pH7.8±n/a
Temperature310.15±n/a K
IC50 183±80 nM
Citation Jones, LHAllan, GBarba, OBurt, CCorbau, RDupont, TKnöchel, TIrving, SMiddleton, DSMowbray, CEPerros, MRingrose, HSwain, NAWebster, RWestby, MPhillips, C Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays (dagger). J Med Chem52:1219-23 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Gag-Pol polyprotein [588-1027,K691N]/[588-1147,K690N]
Name:Gag-Pol polyprotein [588-1027,K691N]/[588-1147,K690N]
Synonyms:HIV-1 Reverse Transcriptase Mutant (K103N)
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [588-1147,K690N]
Synonyms:HIV-1 Reverse Transcriptase Mutant (K103N) Chain A | POL_HV1H2 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:64471.33
Organism:Human immunodeficiency virus type 1
Description:P04585[588-1147,K690N]
Residue:560
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [588-1027,K691N]
Synonyms:HIV-1 Reverse Transcriptase Mutant (K103N) Chain B | POL_HV1H2 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:51322.05
Organism:Human immunodeficiency virus type 1
Description:P04585[588-1027,K691N]
Residue:440
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM27577
poly r(A).oligo d(T)16
Name:poly r(A).oligo d(T)16
Synonyms:n/a
Type:RNA/DNA duplex
Mol. Mass.:358.43
Organism:n/a
Description:Tritium-labeled TTP is co-substrate.
Residue:3
Sequence:
n/a