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TargetComplex of Baculoviral IAP repeat-containing protein 7 [63-159,S150G] and E3 ubiquitin-protein ligase XIAP [336-348]
LigandBDBM27933
Substrate/CompetitorBDBM17342
Meas. Tech.Fluorescence Polarization Affinity Measurements
pH7.2±n/a
Temperature295.15±n/a K
Ki 1500±n/a nM
Citation Cohen, FAlicke, BElliott, LOFlygare, JAGoncharov, TKeteltas, SFFranklin, MCFrankovitz, SStephan, JPTsui, VVucic, DWong, HFairbrother, WJ Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. J Med Chem52:1723-30 (2009) [PubMed]  Article
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Complex of Baculoviral IAP repeat-containing protein 7 [63-159,S150G] and E3 ubiquitin-protein ligase XIAP [336-348]
Name:Complex of Baculoviral IAP repeat-containing protein 7 [63-159,S150G] and E3 ubiquitin-protein ligase XIAP [336-348]
Synonyms:Chimeric protein of melanoma inhibitor of apoptosis protein and XIAP-BIR3 | ML-IAP-BIR | MLXBIR3SG
Type:Chimeric Protein
Mol. Mass.:14953.37
Organism:Homo sapiens (Human)
Description:Q96CA5[63-159,S150G],P98170[336-348]
Residue:133
Sequence:
MGSSHHHHHHSSGEVPRGSHMLETEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPL
TAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKG
QEYINNIHLTHSL
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BDBM27933
BDBM17342
NameBDBM27933
Synonyms:Azabicyclooctane scaffold, 14p | N-[(3aR,6S,6aS)-1-[(2S)-3,3-dimethyl-2-[(2S)-2-(methylamino)propanamido]butanoyl]-octahydrocyclopenta[b]pyrrol-6-yl]-2,3-dihydro-1-benzofuran-3-carboxamide
TypeSmall organic molecule
Emp. Form.C26H38N4O4
Mol. Mass.470.6043
SMILES[H][C@]12CC[C@H](NC(=O)C3COc4ccccc34)[C@@]1([H])N(CC2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C |r|
Structure
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