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TargetComplex of Baculoviral IAP repeat-containing protein 7 [63-159,S150G] and E3 ubiquitin-protein ligase XIAP [336-348]
LigandBDBM27940
Substrate/CompetitorBDBM17342
Meas. Tech.Fluorescence Polarization Affinity Measurements
pH7.2±n/a
Temperature295.15±n/a K
Ki 290±n/a nM
Citation Cohen, FAlicke, BElliott, LOFlygare, JAGoncharov, TKeteltas, SFFranklin, MCFrankovitz, SStephan, JPTsui, VVucic, DWong, HFairbrother, WJ Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. J Med Chem52:1723-30 (2009) [PubMed]  Article
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Complex of Baculoviral IAP repeat-containing protein 7 [63-159,S150G] and E3 ubiquitin-protein ligase XIAP [336-348]
Name:Complex of Baculoviral IAP repeat-containing protein 7 [63-159,S150G] and E3 ubiquitin-protein ligase XIAP [336-348]
Synonyms:Chimeric protein of melanoma inhibitor of apoptosis protein and XIAP-BIR3 | ML-IAP-BIR | MLXBIR3SG
Type:Chimeric Protein
Mol. Mass.:14953.37
Organism:Homo sapiens (Human)
Description:Q96CA5[63-159,S150G],P98170[336-348]
Residue:133
Sequence:
MGSSHHHHHHSSGEVPRGSHMLETEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPL
TAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKG
QEYINNIHLTHSL
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BDBM27940
BDBM17342
NameBDBM27940
Synonyms:(2S)-N-[(2S)-1-[(2S)-2-[(1,1-diphenylacetamido)methyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]-2-(methylamino)propanamide | butoxycarbonylpyrrolidine derivative, 15a
TypeSmall organic molecule
Emp. Form.C29H40N4O3
Mol. Mass.492.6529
SMILESCN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1CNC(=O)C(c1ccccc1)c1ccccc1)C(C)(C)C |r|
Structure
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