Reaction Details |
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Target | Orotidine 5'-phosphate decarboxylase |
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Ligand | BDBM21339 |
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Substrate/Competitor | BDBM21336 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 328.15±n/a K |
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Ki | 134000±5000 nM |
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Citation | Bello, AM; Konforte, D; Poduch, E; Furlonger, C; Wei, L; Liu, Y; Lewis, M; Pai, EF; Paige, CJ; Kotra, LP Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem52:1648-58 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Orotidine 5'-phosphate decarboxylase |
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Name: | Orotidine 5'-phosphate decarboxylase |
Synonyms: | OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) | PYRF_METTH | pyrF |
Type: | Enzyme |
Mol. Mass.: | 24909.45 |
Organism: | Methanobacterium thermoautotrophicum |
Description: | n/a |
Residue: | 228 |
Sequence: | MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFR
KRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREV
FLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISP
GVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP
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BDBM21339 |
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BDBM21336 |
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Name | BDBM21339 |
Synonyms: | 6-Methyl-uridine 5-O-Monophosphate | C6-Uridine Derivative, 16 | JMC521648 Compound 38 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C10H15N2O9P |
Mol. Mass. | 338.2079 |
SMILES | Cc1cc(=O)[nH]c(=O)n1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O |r| |
Structure |
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