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TargetOrotidine 5'-phosphate decarboxylase
LigandBDBM27944
Substrate/CompetitorBDBM21336
Meas. Tech.Enzyme Inhibition Assay
pH7.5±n/a
Temperature328.15±n/a K
Ki 360±30 nM
Citation Bello, AMKonforte, DPoduch, EFurlonger, CWei, LLiu, YLewis, MPai, EFPaige, CJKotra, LP Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem52:1648-58 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Orotidine 5'-phosphate decarboxylase
Name:Orotidine 5'-phosphate decarboxylase
Synonyms:OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) | PYRF_METTH | pyrF
Type:Enzyme
Mol. Mass.:24909.45
Organism:Methanobacterium thermoautotrophicum
Description:n/a
Residue:228
Sequence:
MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFR
KRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREV
FLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISP
GVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM27944
BDBM21336
NameBDBM27944
Synonyms:uridine derivative, 41 | {[(2R,3S,4R,5R)-5-(6-azido-5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Typen/a
Emp. Form.C9H11FN5O9P
Mol. Mass.383.1839
SMILESO[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1c(N=[N+]=[N-])c(F)c(=O)[nH]c1=O |r|
Structure
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