Ki Summary

Reaction Details

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Target

Uridine 5'-monophosphate synthase

Ligand

BDBM27943

Substrate/Competitor

BDBM21336

Meas. Tech.

Enzyme Inhibition Assay

7.5±n/a

Temperature

310.15±n/a K

98000±6000 nM

Citation

Bello, AM; Konforte, D; Poduch, E; Furlonger, C; Wei, L; Liu, Y; Lewis, M; Pai, EF; Paige, CJ; Kotra, LP Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem52:1648-58 (2009) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Uridine 5'-monophosphate synthase

Name:

Uridine 5'-monophosphate synthase

Synonyms:

Orotate phosphoribosyltransferase (HsOPRT) | Orotidine Monophosphate Decarboxylase (ODCase) | UMPS | UMPS_HUMAN

Type:

Enzyme

Mol. Mass.:

52224.99

Organism:

Homo sapiens (Human)

Description:

P11172

Residue:

480

Sequence:

MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL
IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML
EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA
SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP
LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV

BDBM27943

BDBM21336

Name

BDBM27943

Synonyms:

uridine derivative, 39 | {[(2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

Type

n/a

Emp. Form.

C9H12FN2O9P

Mol. Mass.

342.1717

SMILES

O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(F)c(=O)[nH]c1=O |r|

Structure