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TargetEpidermal growth factor receptor [671-1210,L858R]
LigandBDBM27961
Substrate/CompetitorBiotinylated EGFR Peptide Substrate
Meas. Tech.In Vitro Kinase Inhibition Assay
pH7.5±n/a
Temperature296.15±n/a K
IC50 270±n/a nM
Citation Hubbard, RDBamaung, NYFidanze, SDErickson, SAPalazzo, FWilsbacher, JLZhang, QTucker, LAHu, XKovar, POsterling, DJJohnson, EFBouska, JWang, JDavidsen, SKBell, RLSheppard, GS Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases. Bioorg Med Chem Lett19:1718-21 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Epidermal growth factor receptor [671-1210,L858R]
Name:Epidermal growth factor receptor [671-1210,L858R]
Synonyms:EGF-R Tyrosine Kinase Mutant (L858R) | EGFR | EGFR_HUMAN | ERBB | ERBB1 | HER1 | Receptor tyrosine-protein kinase ErbB-1
Type:Intracellular domain
Mol. Mass.:60902.51
Organism:Homo sapiens (Human)
Description:EGFR kinase construct (L858R) was used in enzyme assays.
Residue:540
Sequence:
RHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGL
WIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIT
QLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTF
GSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSK
MARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTS
RTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVP
EYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNST
FDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM27961
Biotinylated EGFR Peptide Substrate
Name:Biotinylated EGFR Peptide Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:3934.43
Organism:n/a
Description:n/a
Residue:34
Sequence:
biotin-(aminohexanoic acid)-EEEEYFELVAKKK-CONH2