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TargetRAF proto-oncogene serine/threonine-protein kinase [1-324]
LigandBDBM202661
Substrate/CompetitorMEK1 (K97R)
Meas. Tech.Raf Activity Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 0.41±n/a nM
Commentsextracted
Citation Aversa, RJBarsanti, PABurger, MDillon, MPDipesa, AHu, CLou, YNishiguchi, GPan, YPolyakov, VRamurthy, SRico, ASetti, LSmith, ASubramanian, STaft, BTanner, HWan, LYusuff, N Biaryl amide compounds as kinase inhibitors US Patent US9694016 Publication Date 7/4/2017
More Info.:Get all data from this article,  Assay Method
 
RAF proto-oncogene serine/threonine-protein kinase [1-324]
Name:RAF proto-oncogene serine/threonine-protein kinase [1-324]
Synonyms:C-Raf TR (aa 1-324) | Proto-oncogene C-Raf (C-Raf TR) | RAF | RAF1 | RAF1_HUMAN
Type:n/a
Mol. Mass.:36996.69
Organism:Homo sapiens (Human)
Description:P04049 (1-324)
Residue:324
Sequence:
QEKNKIRPRGQRDSSEEWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTP
EQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQ
LIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQ
PTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRG
YASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPS
LHRAAHTEDINACTLTTSPRLPVF
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BDBM202661
MEK1 (K97R)
Name:Dual specificity mitogen-activated protein kinase kinase 1 [K97R]
Synonyms:Dual specificity mitogen-activated protein kinase kinase 1 (MEK1)(K97R) | MAP2K1 | MEK1 | MEK1 (K97R) | MP2K1_HUMAN | PRKMK1
Type:n/a
Mol. Mass.:43467.04
Organism:Homo sapiens (Human)
Description:Biotinylated full length MEK1 with an inactivating K97R ATP binding site mutation.
Residue:393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARRLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
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