Reaction Details |
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Target | RAF proto-oncogene serine/threonine-protein kinase [1-324] |
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Ligand | BDBM202661 |
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Substrate/Competitor | MEK1 (K97R) |
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Meas. Tech. | Raf Activity Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 0.41±n/a nM |
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Comments | extracted |
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Citation | Aversa, RJ; Barsanti, PA; Burger, M; Dillon, MP; Dipesa, A; Hu, C; Lou, Y; Nishiguchi, G; Pan, Y; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Subramanian, S; Taft, B; Tanner, H; Wan, L; Yusuff, N Biaryl amide compounds as kinase inhibitors US Patent US9694016 Publication Date 7/4/2017 |
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More Info.: | Get all data from this article, Assay Method |
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RAF proto-oncogene serine/threonine-protein kinase [1-324] |
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Name: | RAF proto-oncogene serine/threonine-protein kinase [1-324] |
Synonyms: | C-Raf TR (aa 1-324) | Proto-oncogene C-Raf (C-Raf TR) | RAF | RAF1 | RAF1_HUMAN |
Type: | n/a |
Mol. Mass.: | 36996.69 |
Organism: | Homo sapiens (Human) |
Description: | P04049 (1-324) |
Residue: | 324 |
Sequence: | QEKNKIRPRGQRDSSEEWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTP
EQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQ
LIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQ
PTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRG
YASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPS
LHRAAHTEDINACTLTTSPRLPVF
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BDBM202661 |
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MEK1 (K97R) |
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Name: | Dual specificity mitogen-activated protein kinase kinase 1 [K97R] |
Synonyms: | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1)(K97R) | MAP2K1 | MEK1 | MEK1 (K97R) | MP2K1_HUMAN | PRKMK1 |
Type: | n/a |
Mol. Mass.: | 43467.04 |
Organism: | Homo sapiens (Human) |
Description: | Biotinylated full length MEK1 with an inactivating K97R ATP binding site mutation. |
Residue: | 393 |
Sequence: | MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARRLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
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