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TargetMitogen-activated protein kinase kinase kinase 8
LigandBDBM28040
Substrate/Competitorbiotin-MEK1-peptide
Meas. Tech.COT HTRF Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 310±n/a nM
Citation Cusack, KAllen, HBischoff, AClabbers, ADixon, RFix-Stenzel, SFriedman, MGaumont, YGeorge, DGordon, TGrongsaard, PJanssen, BJia, YMoskey, MQuinn, CSalmeron, AThomas, CWallace, GWishart, NYu, Z Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production. Bioorg Med Chem Lett19:1722-5 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Mitogen-activated protein kinase kinase kinase 8
Name:Mitogen-activated protein kinase kinase kinase 8
Synonyms:C-COT | COT | COT proto-oncogene serine/threonine-protein kinase | Cancer Osaka thyroid oncogene | ESTF | M3K8_HUMAN | MAP3K8 | Tpl-2 | Tumor Progression Loci-2 Kinase (COT) | Tumor progression locus 2
Type:Serine/threonine-protein kinase
Mol. Mass.:52916.89
Organism:Homo sapiens (Human)
Description:P41279
Residue:467
Sequence:
MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS
KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR
YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE
IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG
MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP
ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM28040
biotin-MEK1-peptide
Name:biotin-MEK1-peptide
Synonyms:n/a
Type:Peptide
Mol. Mass.:2380.63
Organism:n/a
Description:n/a
Residue:24
Sequence:
biotin-AGAGSGQLIDSMANSFVGTR