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TargetGag-Pol polyprotein [1148-1435]
LigandBDBM28269
Substrate/Competitor[3H]Target DNA
Meas. Tech.HIV Integrase Strand Transfer Scintillation Proximity Assay (SPA)
IC50 2±n/a nM
Citation Johns, BA; Weatherhead, JG; Allen, SH; Thompson, JB; Garvey, EP; Foster, SA; Jeffrey, JL; Miller, WH 1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position. Bioorg Med Chem Lett19:1807-10 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Gag-Pol polyprotein [1148-1435]
Name:Gag-Pol polyprotein [1148-1435]
Synonyms:HIV-1 Integrase | POL_HV1H2 | gag-pol
Type:Enzyme
Mol. Mass.:32171.42
Organism:Human immunodeficiency virus type 1
Description:The sequence encoding the 288-amino-acid wild-type full-length integrase was cloned with an N-terminal 6His tag, and expressed in E. coli.
Residue:288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTGATVRAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM28269
[3H]Target DNA
Name:[3H]Target DNA
Synonyms:n/a
Type:Duplex DNA
Mol. Mass.:2689.01
Organism:n/a
Description:n/a
Residue:34
Sequence:
5-AAAAAAATGACCAAGGGCTAATTCACTAAAAAAA-3