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TargetAdenosine deaminase
LigandBDBM28385
Substrate/CompetitorBDBM14487
Meas. Tech.ADA Enzyme Inhibition Assay
pH7.2±n/a
Temperature303.15±n/a K
Ki 2420±190 nM
Citation La Motta, CSartini, SMugnaini, LSalerno, SSimorini, FTaliani, SMarini, AMDa Settimo, FLavecchia, ANovellino, EAntonioli, LFornai, MBlandizzi, CDel Tacca, M Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors. J Med Chem52:1681-92 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Adenosine deaminase
Name:Adenosine deaminase
Synonyms:ADA | ADA_BOVIN | Adenosine aminohydrolase
Type:Enzyme
Mol. Mass.:40910.44
Organism:Bos taurus (bovine)
Description:n/a
Residue:363
Sequence:
MAQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPE
FLAKFDYYMPAIAGCREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAI
DLAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGY
HTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIF
KSTLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPASAE
QCL
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  Blast E-value cutoff:
BDBM28385
BDBM14487
NameBDBM28385
Synonyms:3-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-2-yl}methyl)phenyl]-1-phenylurea | pyrazolo[3,4-d]pyrimidin-4-one, 14a
TypeSmall organic molecule
Emp. Form.C19H16N6O2
Mol. Mass.360.3693
SMILESO=C(Nc1ccccc1)Nc1ccc(Cn2cc3c(n2)nc[nH]c3=O)cc1
Structure
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